Paper Report for: Jones_2007_Neuropharmacol_53_197
Reference
Title: Targeting the cholinergic system as a therapeutic strategy for the treatment of pain Jones PG, Dunlop J Ref: Neuropharmacology, 53:197, 2007 : PubMed
Acetylcholine mediates its effects through both the nicotinic acetylcholine receptors (ligand-gated ion channels) and the G protein-coupled muscarinic receptors. It plays pivotal roles in a diverse array of physiological processes and its activity is controlled through enzymatic degradation by acetylcholinesterase. The effects of receptor agonists and enzyme inhibitors, collectively termed cholinomimetics, in antinociception/analgesia are well established. These compounds successfully inhibit pain signaling in both humans and animals and are efficacious in a number of different preclinical and clinical pain models, suggesting a broad therapeutic potential. In this review we examine and discuss the evidence for the therapeutic exploitation of the cholinergic system as an approach to treat pain.
        
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Jones PG, Dunlop J (2007) Targeting the cholinergic system as a therapeutic strategy for the treatment of pain Neuropharmacology53: 197-206
Jones PG, Dunlop J (2007) Neuropharmacology53: 197-206