Title: ABHD12 Knockdown Suppresses Breast Cancer Cell Proliferation, Migration and Invasion Jun S, Kim SW, Lim JY, Park SJ Ref: Anticancer Research, 40:2601, 2020 : PubMed
BACKGROUND/AIM: Alpha/beta-hydrolase domain containing 12 (ABHD12) is a serine hydrolase that regulates immunological and neurological mechanisms. This study aimed to elucidate the oncogenic effect of ABHD12 on human breast cancer. MATERIALS AND METHODS: ABHD12 expression was confirmed in breast cancer tissues and breast cancer cell lines by immunohistochemistry and quantitative RT-PCR. To determine the role of ABHD12, ABHD12 siRNA-suppressed breast cancer cells (MCF7 and MDA-MB-231 cells) were investigated for cell proliferation, migration, and invasion capabilities using MTT assays, EdU assays, colony formation assays, and Boyden chamber assays. RESULTS: Immunohistochemical staining showed a higher ABHD12 expression in breast cancer tissues than in normal tissues. Additionally, ABHD12 knockdown was found to inhibit cell growth, proliferation, migration, and invasion in breast cancer cells. CONCLUSION: ABHD12 plays a crucial role in cell proliferation, migration, and invasion of breast cancer cells.
Jun S, Kim SW, Lim JY, Park SJ (2020) ABHD12 Knockdown Suppresses Breast Cancer Cell Proliferation, Migration and Invasion Anticancer Research40: 2601-2611
Jun S, Kim SW, Lim JY, Park SJ (2020) Anticancer Research40: 2601-2611
