Paper Report for: Kanakubo_2006_Bioorg.Med.Chem.Lett_16_4648
Reference
Title: The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)-C(1)-epiepiquinamide Kanakubo A, Gray D, Innocent N, Wonnacott S, Gallagher T Ref: Bioorganic & Medicinal Chemistry Lett, 16:4648, 2006 : PubMed
The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [(3)H]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity.
        
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Kanakubo A, Gray D, Innocent N, Wonnacott S, Gallagher T (2006) The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)-C(1)-epiepiquinamide Bioorganic & Medicinal Chemistry Lett16: 4648-51
Kanakubo A, Gray D, Innocent N, Wonnacott S, Gallagher T (2006) Bioorganic & Medicinal Chemistry Lett16: 4648-51