Title: Ostalactones A-C, beta- and epsilon-Lactones with Lipase Inhibitory Activity from the Cultured Basidiomycete Stereum ostrea Kang HS, Kim JP Ref: Journal of Natural Products, 79:3148, 2016 : PubMed
Ostalactones A-C (1-3), three new beta- and epsilon-lactone natural products, were isolated from the culture broth of the basidiomycete Stereum ostrea. The structures were elucidated by interpretation of HRFABMS and 1D and 2D NMR data. The structures of 1 and 2 are characterized by the presence of a beta-lactone containing a fused 4/5 bicyclic core structure. Compound 3 possesses a 2-oxepinone ring system, which is likely to be a biosynthetic precursor of compounds 1 and 2. Ostalactones A (1) and B (2) displayed potent inhibitory activity against human pancreatic lipase.
        
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Kang HS, Kim JP (2016) Ostalactones A-C, beta- and epsilon-Lactones with Lipase Inhibitory Activity from the Cultured Basidiomycete Stereum ostrea Journal of Natural Products79: 3148-3151
Kang HS, Kim JP (2016) Journal of Natural Products79: 3148-3151