Paper Report for: Karschin_1994_Eur.J.Neurosci_6_1756
Reference
Title: Fast inhibition of inwardly rectifying K+ channels by multiple neurotransmitter receptors in oligodendroglia Karschin A, Wischmeyer E, Davidson N, Lester HA Ref: European Journal of Neuroscience, 6:1756, 1994 : PubMed
An essential function of myelinating oligodendroglia in the mammalian central nervous system is the regulation of extracellular potassium levels by means of a prominent inwardly rectifying K+ current. Cardiac and neuronal K+ inward rectifiers are either activated by hyperpolarizing voltages or controlled by neurotransmitters through the action of receptor-activated G proteins. Neuromodulation of inward rectifiers has not previously been considered as a way to regulate oligodendrocyte function. Here we report the expression of serotonin, somatostatin and muscarinic acetylcholine G protein-coupled receptors in rat brain oligodendrocytes. Activation of these receptors leads to pertussis toxin-sensitive inhibition of inwardly rectifying K+ channels within < 1 s. By contrast, in the heart and in neurons, similar pathways activate an inwardly rectifying conductance. Thus, transmitter-mediated blockade of inward rectifiers appears to be an oligodendrocyte-specific variation of a common motif for convergent signalling pathways. In vivo, expression of this mechanism, which may be dependent on neuron-glia signalling, may have a regulatory role in K+ homeostasis during neuron activity in the central nervous system.
        
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Karschin A, Wischmeyer E, Davidson N, Lester HA (1994) Fast inhibition of inwardly rectifying K+ channels by multiple neurotransmitter receptors in oligodendroglia European Journal of Neuroscience6: 1756-64
Karschin A, Wischmeyer E, Davidson N, Lester HA (1994) European Journal of Neuroscience6: 1756-64