Paper Report for: Kassa_2004_Mil.Med.Sci.Lett_73_142
Reference
Title: The Effect of Repeated Antidotal Treatment on Tabun-Induced Toxicity in Mice Kassa J Ref: Military Medical Science Letters, 73:142, 2004 : PubMed
Male NMRI mice were used to test the effect of single or repeated antidotal treatment with various oximes (pralidoxime, obidoxime, trimedoxime, the oxime HI-6) in combination with an anticholinergic drug atropine on the acute toxicity of organophosphorus tabun compound with the help of evaluating medial lethal (LD50) dose at a 24-hour survival of tabun-poisoned experimental animals.If some of the tested oximes in combination with atropine were administered repeatedly during acute tabun intoxication, a slight increase in the LD50 value was observed compared to a single administration when pralidoxime or obidoxime was used as an acetylcholinesterase reactivator. This means that the repeated administration of observed antidotal mixtures does not bring a significant improvement in the efficacy of antidotal treatment of acute tabun poisoning. The comparison of the therapeutic effects of tested oximes shows that trimedoxime seems to be the most suitable oxime for decreasing the acute tabun toxicity.The results confirm that no currently used oxime is sufficiently effective for eliminating acute tabun toxicity. Trimedoxime appears to be a prospective acetylcholinesterase reactivator for the antidotal treatment of tabun poisoning. The repeated administration of antidotes during acute tabun poisoning does not show a significant increase in the therapeutical efficacy of antidotal treatment of acute tabun poisoning