Paper Report for: Killen_1985_J.Neuroimmunol_9_229
Reference
Title: The main immunogenic region of acetylcholine receptors does not provoke the formation of antibodies of a predominant idiotype Killen JA, Hochschwender SM, Lindstrom JM Ref: Journal of Neuroimmunology, 9:229, 1985 : PubMed
Anti-idiotype antibodies were induced in rats by immunization with rat monoclonal antibodies to the main immunogenic region of acetylcholine receptors. These anti-idiotype antibodies showed very little crossreaction with other rat monoclonal antibodies which bind to the same region of the receptor. When the rats producing these anti-idiotype antibodies were immunized with receptor, they showed no net decrease in anti-receptor antibody production. These data indicate that, although more than half of the antibodies produced by rats immunized with receptor are directed at a small region, many anti-receptor idiotypes are involved in this response and anti-idiotype therapy is not beneficial.
        
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Killen JA, Hochschwender SM, Lindstrom JM (1985) The main immunogenic region of acetylcholine receptors does not provoke the formation of antibodies of a predominant idiotype Journal of Neuroimmunology9: 229-41
Killen JA, Hochschwender SM, Lindstrom JM (1985) Journal of Neuroimmunology9: 229-41