A longitudinal characteristic curve of chronic liver disease (LCC-LD) is derived for the first time by a new method of time series data analysis, where a hospital information system is utilized as a clinical research application of the database. It describes a typical pattern of development of disease from the beginning of chronic hepatitis to the final stage of cirrhosis. The LCC-LD is obtained by effectively using patient data with various stages of developments of liver disease and the present method is applicable to derive the LCC of other diseases. The obtained LCC-LD may be useful for a clinical decision making support such as the prospective assessment (for example, the onset time of cirrhosis) of liver disease in individual patients, an evaluation of drug effect, etc.
        
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Kitazoe Y, Kurihara Y, Okuhara Y, Onishi S, Tomita A, Yamamoto Y, Nishioka Y, Sasaki M, Yamamoto K, Nose Y (1995) Longitudinal characteristic curve of liver disease Computers in Biology & Medicine25: 39-47
Kitazoe Y, Kurihara Y, Okuhara Y, Onishi S, Tomita A, Yamamoto Y, Nishioka Y, Sasaki M, Yamamoto K, Nose Y (1995) Computers in Biology & Medicine25: 39-47