Paper Report for: Kobayashi_2010_Biotechnol.Lett_32_1679
Reference
Title: Efficient synthesis of 6-O-palmitoyl-1,2-O-isopropylidene-alpha-D-glucofuranose in an organic solvent system by lipase-catalyzed esterification Kobayashi T, Ehara T, Mizuoka T, Adachi S Ref: Biotechnol Lett, 32:1679, 2010 : PubMed
In order to synthesize a sugar ester at high concentration, 1,2-O-isopropylidene-alpha-D-glucofuranose (IpGlc), which is one of the sugar acetals and is more hydrophobic than unmodified glucose, was esterified with palmitic acid at 40 degrees C using immobilized lipase from Candida antarctica in some organic solvents or their mixtures. Acetone + t-butyl alcohol (3:1 v/v) improved both the initial reaction rate and yield after 80 h: the product reached its maximum value (240 mmol/kg solvent; ca. 110 g/kg solvent) when 400 mmol IpGlc/kg solvent and 1,200 mmol palmitic acid/kg solvent were used in this solvent mixture.
        
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Kobayashi T, Ehara T, Mizuoka T, Adachi S (2010) Efficient synthesis of 6-O-palmitoyl-1,2-O-isopropylidene-alpha-D-glucofuranose in an organic solvent system by lipase-catalyzed esterification Biotechnol Lett32: 1679-84