Paper Report for: Koelle_1976_Proc.Natl.Acad.Sci.U.S.A_73_2936
Reference
Title: Effects of persistent selective suppression of ganglionic butyrylcholinesterase on steady state and regenerating levels of acetylcholinesterase: implications regarding function of butyrylcholinesterase and regulation of protein synthesis Koelle WA, Koelle GB, Smyrl EG Ref: Proceedings of the National Academy of Sciences of the United States of America, 73:2936, 1976 : PubMed
Persistent selective suppression of the butyrylcholinesterase (cholinesterase; acylcholine acyl-hydrolase, EC 3.1.1.8) activity of the superior cervical, stellate, and ciliary ganglia of cats by the daily administration of tetramonoisopropyl pyrophosphortetramide, 3.0 mumol/kg, intravenously, for 6 days produced a significant elevation in the levels of ganglionic acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7). When the same procedure was preceded by the inactivation of over 95% of the ganglionic acetylcholinesterase by sarin, 2.0 mumol/kg, intravenously, the rate of regeneration of acetylcholinesterase was decreased. Results are interpreted as evidence that ganglionic butyrylcholinesterase may serve as a precursor to acetylcholinesterase, and that the level of butyrylcholinesterase may regulate the rate of acetylcholinesterase synthesis.
        
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Koelle WA, Koelle GB, Smyrl EG (1976) Effects of persistent selective suppression of ganglionic butyrylcholinesterase on steady state and regenerating levels of acetylcholinesterase: implications regarding function of butyrylcholinesterase and regulation of protein synthesis Proceedings of the National Academy of Sciences of the United States of America73: 2936-8
Koelle WA, Koelle GB, Smyrl EG (1976) Proceedings of the National Academy of Sciences of the United States of America73: 2936-8