AIMS The aim of this study was to determine the allele frequencies of resistance to inhibitors of cholinesterase 3 homologue RIC-3 gene rs1528133 polymorphism in overweight+obese+morbid obese and non-obese non-OB subjects The effects of rs1528133 genotypes on anthropometric diabetes and obesity related parameters self-reported macronutrient intake and drugs were also evaluated The study was performed on overweight+obese+morbid obese and non-obese subjects METHODS RIC-3 gene rs1528133 genotypes were determined with qPCR RESULTS The RIC-3 rs1528133 genotype frequencies were respectively as 89.4 for homozygous wild type A/A 10.6 for heterozygous A/C genotypes in overweight+obese+morbid obese patients and 92.7 for A/A 7.3 for A/C genotypes in non-OB subjects The homozygous mutant genotype C/C was not detected in our study population Genotype frequencies were not significantly different among study groups Heterozygous genotype carriers for the rs1528133 polymorphism were found to prefer higher glycemic load fat and protein diet content compared to homozygous wild type genotype carriers p=0.0001 The frequency of rs1528133 heterozygous individuals 16.7 using antihypertensive drugs was lower p=0.045 in comparison to wild type genotype carriers 46.9 in the whole study population CONCLUSIONS RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter but associated with higher glycemic load protein and fat eating behavior and antihypertensive drug use.
        
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Koldemir M, Kahveci C, Bayer H, Cagatay P, Yildiz S, Bagriacik N, Susleyici-Duman B (2012) Relationship of RIC-3 gene rs1528133 polymorphism with varying degrees of body weight and eating behavior Diabetes Metab Syndr6: 90-5
Koldemir M, Kahveci C, Bayer H, Cagatay P, Yildiz S, Bagriacik N, Susleyici-Duman B (2012) Diabetes Metab Syndr6: 90-5