Paper Report for: Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_167
Reference
Title: 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents Kuca K, Dohnal V Ref: Acta Medica (Hradec Kralove), 47:167, 2004 : PubMed
The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator--pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10(-4) M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10(-1) M (for cyclosarin) and 10(-3) M (for VX) but these concentrations are not available for the use in vivo.
        
Related information
Citations formats
Kuca K, Dohnal V (2004) 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents Acta Medica (Hradec Kralove)47: 167-9
Kuca K, Dohnal V (2004) Acta Medica (Hradec Kralove)47: 167-9