A small library of novel spiropyrrolidine heterocyclic hybrids has been prepared regioselectively in 1-butyl-3-methylimidazoliumbromide ([bmim]Br) with good to excellent yields using a [3+2] cycloaddition reaction. These synthesized compounds were evaluated as potential agents for treating Alzheimer's disease. Compound 4b showed the most potent activity, with an IC50 of 7.9+/-0.25microM against acetylcholinesterase (AChE). The inhibition mechanisms for the most active compounds on AChE and butyrylcholinesterase (BChE) receptors were elucidated using molecular docking simulations.
        
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Kumar RS, Almansour AI, Arumugam N, Althomili DMQ, Altaf M, Basiri A, D K, Sai Manohar T, S V (2018) Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines Bioorg Chem77: 263-268
Kumar RS, Almansour AI, Arumugam N, Althomili DMQ, Altaf M, Basiri A, D K, Sai Manohar T, S V (2018) Bioorg Chem77: 263-268