Paper Report for: Lee_1976_Arch.Environ.Contam.Toxicol_4_443
Reference
Title: Penetration and comparative metabolism of leptophos in susceptible and resistant houseflies Lee PW, Fukuto TR Ref: Archives of Environmental Contamination & Toxicology, 4:443, 1976 : PubMed
The metabolism and rate of penetration of leptophos (O-methyl O-4-bromo-2,5-dichlorophenyl phenylphosphonothioate) was determined in a susceptible strain and a strain of housefies which was 50-fold resistant to leptophos. Penetration of leptophos into resistant flies was substantially slower than into susceptible flies but large differences in metabolism, both quantitatively and qualitatively, were not observed. No difference was observed in the sensitivity of flyhead and thorax acetylcholinesterase to leptophos-oxon in vitro, and tolerance to leptophos by the resistant strain is explained in terms of decreased rates or penetration and minor differences in metabolism.
        
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Citations formats
Lee PW, Fukuto TR (1976) Penetration and comparative metabolism of leptophos in susceptible and resistant houseflies Archives of Environmental Contamination & Toxicology4: 443-55
Lee PW, Fukuto TR (1976) Archives of Environmental Contamination & Toxicology4: 443-55