Paper Report for: Lee_1989_Eur.J.Pharmacol_167_295
Reference
Title: Methoctramine, a cardioselective muscarinic antagonist, stimulates phosphoinositide hydrolysis in rat cerebral cortex Lee NH, Forray C, El-Fakahany EE Ref: European Journal of Pharmacology, 167:295, 1989 : PubMed
The cardioselective muscarinic antagonist methoctramine antagonized carbamylcholine-mediated phosphoinositide (PI) hydrolysis in a concentration-dependent fashion in dissociated rat cerebrocortical cells. However, as the concentration of methoctramine was increased above 5 microM, there was a reversal of the antagonism of the PI response. In the absence of carbamylcholine, methoctramine by itself significantly increased PI hydrolysis with a maximal effect at 30 microM. Various classes of receptor antagonists, including atropine, and ion-channel blockers were unable to block methoctramine-stimulated PI hydrolysis.
Lee NH, Forray C, El-Fakahany EE (1989) Methoctramine, a cardioselective muscarinic antagonist, stimulates phosphoinositide hydrolysis in rat cerebral cortex European Journal of Pharmacology167: 295-8
Lee NH, Forray C, El-Fakahany EE (1989) European Journal of Pharmacology167: 295-8