Paper Report for: Lee_2009_Bioorg.Med.Chem.Lett_19_860
Reference
Title: Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells Lee SH, Park JS, Kim SK, Ahn CB, Je JY Ref: Bioorganic & Medicinal Chemistry Lett, 19:860, 2009 : PubMed
Clinical applications of acetylcholinesterase (AChE) inhibitors are widespread in Alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. In this study, six kinds of chitooligosaccharides (COSs) with different molecular weight and degree of deacetylation were examined for their inhibitory effects against AChE. The 90-COSs exhibited potent AChE inhibitory activities compared to 50-COSs, while 90-MMWCOS (1000-5000 Da) in the 90-COSs showed the highest activity. Cell culture experiment revealed that 90-MMWCOS suppressed the level of AChE protein expression and AChE activity induced by Abeta(25-35) in PC12 cell lines.
        
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Lee SH, Park JS, Kim SK, Ahn CB, Je JY (2009) Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells Bioorganic & Medicinal Chemistry Lett19: 860-2
Lee SH, Park JS, Kim SK, Ahn CB, Je JY (2009) Bioorganic & Medicinal Chemistry Lett19: 860-2