Paper Report for: Liao_1995_Fundam.Appl.Toxicol_27_90
Reference
Title: An explanation on the limited efficacy of detoxication against VX toxicity by purified specific antibodies Liao WG, Rong KT Ref: Fundamental & Applied Toxicology, 27:90, 1995 : PubMed
Studies on the mechanism of detoxication against VX toxicity by purified rabbit anti-VX antibodies were carried out in mice. VX (25 micrograms/kg) was injected subcutaneously immediately following intravenous injection of purified anti-VX antibodies. Blood concentration of free VX declined linearly as the antibody dose increased. Free VX concentration in brain was far lower than that in blood. When the dose of purified anti-VX antibodies was 8 and 6 mg/kg, respectively, free VX concentration in brain and blood approached 0. At the same time, the cholinesterase (ChE) activity in brain increased along with increasing antibody dose, with 70% of normal control value detected when 8 mg/kg antibodies were administered. On the other hand, anti-VX antibodies were not able to protect blood ChE unless the VX dose was lower than 10 micrograms/kg. The studies suggest that the protective action of purified rabbit anti-VX antibodies is from VX antibodies combining with the free VX in blood and extravascular tissue to reduce the amount of VX entering into the brain.
Liao WG, Rong KT (1995) An explanation on the limited efficacy of detoxication against VX toxicity by purified specific antibodies Fundamental & Applied Toxicology27: 90-4
Liao WG, Rong KT (1995) Fundamental & Applied Toxicology27: 90-4