Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata . Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an alpha-oxo-beta-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 muM, respectively.
        
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Liu JQ, Peng XR, Li XY, Li TZ, Zhang WM, Shi L, Han J, Qiu MH (2013) Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree (Malpighia emarginata) Org Lett15: 1580-3
Liu JQ, Peng XR, Li XY, Li TZ, Zhang WM, Shi L, Han J, Qiu MH (2013) Org Lett15: 1580-3