Paper Report for: Majima_1995_Eur.J.Pharmacol_284_1
Reference
Title: Ebelactone B, an inhibitor of urinary carboxypeptidase Y-like kininase, prevents the development of deoxycorticosterone acetate-salt hypertension in rats Majima M, Ikeda Y, Kuribayashi Y, Mizogami S, Katori M, Aoyagi T Ref: European Journal of Pharmacology, 284:1, 1995 : PubMed
Kininogen-deficient Brown Norway Katholiek rats (BN-Ka) excrete little urinary kinin, compared with normal rats of the same strain (BN Kitasato rats (BN-Ki)). Deoxycorticosterone acetate-salt treatment increased systolic blood pressure in both rats, but much faster in BN-Ka than in BN-Ki. Daily subcutaneous administration of ebelactone B (15 and 5 mg/kg/day), a rat urinary carboxypeptidase Y-like kininase inhibitor, significantly reduced systolic blood pressure in BN-Ki, but not in BN-Ka. This treatment significantly increased urinary Na+ excretion and reduced Na+ concentration in the erythrocytes in BN-Ki, but not in BN-Ka. An angiotensin-converting enzyme inhibitor, lisinopril (5 mg/kg/day s.c.), did not reduce the systolic blood pressure in either BN-Ki or BN-Ka. These results suggested that ebelactone B has promise as a preventive agent for the development of hypertension acting through the inhibition of urinary kinin degradation.
        
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Majima M, Ikeda Y, Kuribayashi Y, Mizogami S, Katori M, Aoyagi T (1995) Ebelactone B, an inhibitor of urinary carboxypeptidase Y-like kininase, prevents the development of deoxycorticosterone acetate-salt hypertension in rats European Journal of Pharmacology284: 1-11
Majima M, Ikeda Y, Kuribayashi Y, Mizogami S, Katori M, Aoyagi T (1995) European Journal of Pharmacology284: 1-11