Paper Report for: Maryamabadi_2017_Bioorg.Med.Chem_25_2057
Reference
Title: Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity Maryamabadi A, Hasaninejad A, Nowrouzi N, Mohebbi G Ref: Bioorganic & Medicinal Chemistry, 25:2057, 2017 : PubMed
A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N'-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and butyrylcholinesterases were investigated both in vitro and in silico. All compounds showed moderate level activity against both acetyl and butyrylcholinesterases.
        
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Maryamabadi A, Hasaninejad A, Nowrouzi N, Mohebbi G (2017) Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity Bioorganic & Medicinal Chemistry25: 2057-2064
Maryamabadi A, Hasaninejad A, Nowrouzi N, Mohebbi G (2017) Bioorganic & Medicinal Chemistry25: 2057-2064