Paper Report for: Matsumoto_1995_J.Neur.Transm_100_1
Reference
Title: The neurotrophic effects of ebiratide, an analog of ACTH4-9, on cultured septal cells and aged rats Matsumoto T, Tsuda S, Nakamura S Ref: Journal of Neural Transmission General Section, 100:1, 1995 : PubMed
The neurotrophic effects of ebiratide, an ACTH4-9 analog, have been examined using both fetal rat septal cultures and aged rats. The 5-day treatment with ebiratide (10-100 pmol/ml) partially prevented neuronal degeneration that occurred in the cultures in which cells were sparsely plated. Ebiratide (10 pmol/ ml) increased choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities up to 1.5 and 1.2 times the respective control values in the sub-confluent cultures. AChE cytochemistry of the cultures has shown that ebiratide increased the stained area per cell. Ebiratide subcutaneously administered by constant infusion (10 nmol/body/hr) for 4 weeks elevated ChAT activities in the septum (35% over control), neocortex (79%) and hippocampus (89%) of aged rats. Thus, the present study indicates that ebiratide shares neurotrophic properties which may prove beneficial in the therapy for CNS degenerative disorders, especially Alzheimer's disease.
        
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Matsumoto T, Tsuda S, Nakamura S (1995) The neurotrophic effects of ebiratide, an analog of ACTH4-9, on cultured septal cells and aged rats Journal of Neural Transmission General Section100: 1-15
Matsumoto T, Tsuda S, Nakamura S (1995) Journal of Neural Transmission General Section100: 1-15