Paper Report for: Mccain_1993_Pestic.Biochem.Physiol_45_220
Reference
Title: The Effect of Phenyl Saligenin Cyclic Phosphate Induced Delayed Neuropathy on Selected Hemodynamic and Hematologic Parameters in the Hen McCain WC, Lee JC, Wilcke JR, Ehrich M Ref: Pesticide Biochemistry and Physiology, 45:220, 1993 : PubMed
Cardiovascular parameters, including limb venous flow and arterial blood pressure, were measured 1, 3, 7, and 15-21 days after a single 2.5 mg/kg intramuscular injection of phenyl saligenin cyclic phosphate (PSP) was administered to hens. All hens given the organophosphate developed clinical signs of delayed neuropathy by Day 10 and these signs were maximal by Day 20 after PSP administration. Resistance to blood flow was increased in the legs of hens given PSP prior to the onset of clinical signs of organophosphorus-induced delayed neuropathy (OPIDN). This did not occur in hens given an OP that did not cause OPIDN (paraoxon). PSP administration also resulted in significant decreases in the activities of brain neurotoxic esterase (NTE) and plasma cholinesterase, as well as decreases in body weight prior to evidence of clinical signs of OPIDN. When maximal signs of OPIDN were present, activities of brain NTE and plasma cholinesterase had returned to control levels. Limb venous flow and arterial blood pressure were elevated in PSP-treated hens when maximal clinical signs were evident (Days 15-21). Body weight and arterial PCO2 were also significantly decreased in hens with OPIDN and hematocrit significantly increased. Administration of this neuropathy-inducing organophosphate was, therefore, capable of altering hemodynamic and hematologic parameters before and after onset of OPIDN.
        
Related information
Citations formats
McCain WC, Lee JC, Wilcke JR, Ehrich M (1993) The Effect of Phenyl Saligenin Cyclic Phosphate Induced Delayed Neuropathy on Selected Hemodynamic and Hematologic Parameters in the Hen Pesticide Biochemistry and Physiology45: 220-227
McCain WC, Lee JC, Wilcke JR, Ehrich M (1993) Pesticide Biochemistry and Physiology45: 220-227