Paper Report for: Mittra_2001_Acta.Pharmacol.Sin_22_37
Reference
Title: Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride Mittra S, Peshin SS, Lall SB Ref: Acta Pharmacol Sin, 22:37, 2001 : PubMed
AIM To investigate the cholinesterase inhibition and effect of atropine and pralidoxime (PAM) treatment on the survival time in the rat model of aluminium phosphide (AlP) poisoning.
METHODS:
The rats were treated with AlP (10 mg/kg; 5.55 x LD50; ig) and the survival time was noted. The effect of atropine (1 mg/kg, ip) and PAM (5 mg/kg, ip) was noted on the above. Atropine and PAM were administered 5 min after AlP. Plasma cholinesterase levels were measured spectrophotometrically in the control and AlP treated rats 30 min after administration.
RESULTS:
Treatment with atropine and PAM increased the survival time by 2.5 fold (1.4 h+/-0.3 h vs 3.4 h+/-2.5 h, P < 0.01) in 9 out of 15 animals and resulted in total survival of the 6 remaining animals. Plasma cholinesterase levels were inhibited by 47 %, (438+/-74) U/L in AlP treated rats as compared to control (840+/-90) U/L (P < 0.01).
CONCLUSION:
This preliminary study concludes that AlP poisoning causes cholinesterase inhibition and responds to treatment with atropine and PAM.
        
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Citations formats
Mittra S, Peshin SS, Lall SB (2001) Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride Acta Pharmacol Sin22: 37-39