Paper Report for: Moser_1995_Proc.Natl.Acad.Sci.U.S.A_92_9697
Reference
Title: Spatial learning with a minislab in the dorsal hippocampus Moser MB, Moser EI, Forrest E, Andersen P, Morris RG Ref: Proceedings of the National Academy of Sciences of the United States of America, 92:9697, 1995 : PubMed
We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support spatial learning in a water maze, provided it was at the septal (dorsal) pole of the hippocampus. Lesions of the septal pole, leaving 60% of the hippocampi intact, caused a learning deficit, although normal electrophysiological responses, synaptic plasticity, and preserved acetylcholinesterase staining argue for adequate function of the remaining tissue. Thus, with an otherwise normal brain, hippocampal-dependent spatial learning only requires a minislab of dorsal hippocampal tissue.
        
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Moser MB, Moser EI, Forrest E, Andersen P, Morris RG (1995) Spatial learning with a minislab in the dorsal hippocampus Proceedings of the National Academy of Sciences of the United States of America92: 9697-701
Moser MB, Moser EI, Forrest E, Andersen P, Morris RG (1995) Proceedings of the National Academy of Sciences of the United States of America92: 9697-701