Paper Report for: Murakami_1997_Jpn.J.Pharmacol_75_443
Reference
Title: Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats Murakami Y, Tanaka E, Sakai Y, Matsumoto K, Li HB, Watanabe H Ref: Japanese Journal of Pharmacology, 75:443, 1997 : PubMed
Effect of tacrine, a cholinesterase inhibitor, on spatial acquisition deficit caused by permanent occlusion of bilateral common carotid arteries (2VO) was examined by using the conventional 8-arm and the 4-arm baited radial maze tasks in rats. Daily administration of tacrine (0.1 and 0.3 mg/kg, i.p.) 1 month after 2VO operation significantly improved the impaired spatial acquisition in the conventional maze task. This treatment also ameliorated the 2VO-induced working but not reference memory deficit in the 4-arm baited radial maze task. These results suggest that tacrine improvement of working memory deficit in the 2VO rats is due to stimulation of central cholinergic systems.
        
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Murakami Y, Tanaka E, Sakai Y, Matsumoto K, Li HB, Watanabe H (1997) Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats Japanese Journal of Pharmacology75: 443-6
Murakami Y, Tanaka E, Sakai Y, Matsumoto K, Li HB, Watanabe H (1997) Japanese Journal of Pharmacology75: 443-6