Paper Report for: Nakamura_2015_Dement.Geriatr.Cogn.Dis.Extra_5_361
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Title: A 24-Week, Randomized, Controlled Study to Evaluate the Tolerability, Safety and Efficacy of 2 Different Titration Schemes of the Rivastigmine Patch in Japanese Patients with Mild to Moderate Alzheimer's Disease Nakamura Y, Strohmaier C, Tamura K, Kataoka N, Nakano M, Oda S, Nishimura K, Homma A Ref: Dement Geriatr Cogn Dis Extra, 5:361, 2015 : PubMed
AIM: To investigate whether 1-step titration of the rivastigmine patch (initiated at 5 cm(2) and titrated to 10 cm(2) after 4 weeks) is well tolerated in Japanese patients with Alzheimer's disease (AD) as compared to 3-step titration (initiated at 2.5 cm(2) and titrated by 2.5 cm(2) every 4 weeks to 10 cm(2)). METHODS: A 24-week, multicenter, randomized, double-blind study was conducted in Japan between July 2012 and May 2014. Patients with mild to moderate AD aged 50-85 years were randomized 1:1 to 1-step or 3-step titration of the rivastigmine once-daily patch. The primary endpoint was the proportion of patients with adverse events leading to discontinuation. RESULTS: Of 216 patients randomized, 215 (1-step, n = 107; 3-step, n = 108) were included in the safety analysis. The primary endpoint outcome was 15.0% in the 1-step group and 18.5% in the 3-step group. The observed treatment difference was -3.6% (95% confidence interval: -17.0, 9.6), falling within the prespecified acceptance range. CONCLUSION: The tolerability of two different titration schemes was similar in Japanese patients with AD.
        
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Nakamura Y, Strohmaier C, Tamura K, Kataoka N, Nakano M, Oda S, Nishimura K, Homma A (2015) A 24-Week, Randomized, Controlled Study to Evaluate the Tolerability, Safety and Efficacy of 2 Different Titration Schemes of the Rivastigmine Patch in Japanese Patients with Mild to Moderate Alzheimer's Disease Dement Geriatr Cogn Dis Extra5: 361-74
Nakamura Y, Strohmaier C, Tamura K, Kataoka N, Nakano M, Oda S, Nishimura K, Homma A (2015) Dement Geriatr Cogn Dis Extra5: 361-74