We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in the brain cytosol fraction from BPMP-injected rats. The phosphorylating activity of rat brain membrane fractions were enhanced by BPMP treatment. The brain membrane fractions from BPMP-treated rats phosphorylated several proteins, including supposedly PLCgamma in the brain cytosol fraction from control rats in vitro. These results suggest that soman and sarin may stimulate a membrane tyrosine kinase, including growth factor receptors, directly or indirectly.
Niijima H, Nagao M, Nakajima M, Takatori T, Matsuda Y, Iwase H, Kobayashi M (1999) Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains Toxicol Appl Pharmacol156: 64-9
Niijima H, Nagao M, Nakajima M, Takatori T, Matsuda Y, Iwase H, Kobayashi M (1999) Toxicol Appl Pharmacol156: 64-9
