Title: The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system Nomura J, Hosoi T, Okuma Y, Nomura Y Ref: Life Sciences, 72:2121, 2003 : PubMed
The existence and functions of muscarinic acetylcholine (mACh) receptors in human T lymphocytes were investigated. RT-PCR analysis demonstrated the presence of M(1) and M(2) subtypes of mACh receptors in human T lymphocytes. Pretreatment with oxotremorine-M (Oxo-M) caused the increase in phytohemagglutinin-induced IL-2 production. Since 4-DAMP suppressed Oxo-M-caused enhancement in IL-2 production, M(1) receptors seem to be involved in the enhancement of the production. Oxo-M stimulated IL-2 receptor mRNA expression and DNA synthesis. Our results suggest that muscarinic receptors, perhaps M(1) receptors are involved in the enhancement of TCR-induced IL-2 production and IL-2 receptor expression in human T lymphocytes. Thus muscarinic receptors positively modulate cell growth in human T lymphocytes by the autocrine mechanism through enhancing expression of both IL-2 and the receptors.
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Nomura J, Hosoi T, Okuma Y, Nomura Y (2003) The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system Life Sciences72: 2121-6
Nomura J, Hosoi T, Okuma Y, Nomura Y (2003) Life Sciences72: 2121-6
