Paper Report for: Ozaslan_2022_Chem.Biodivers__e202200280
Reference
Title: Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity Ozaslan MS, Saglamtas R, Demir Y, Genc Y, Saracoglu I, Gulcin I Ref: Chem Biodivers, :e202200280, 2022 : PubMed
In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe(3+) and Cu(2+) reductive ability and Fe(2+) chelating effects. The inhibitory effects of isolated phenolic compounds were tested towards human carbonic anhydrase I and II isoenzymes (hCAI and hCAII), butyrylcholinesterase (BChE) acetylcholinesterase (AChE), aldose reductase (AR) and alpha-glycosidase (alpha-gly). K(i) values were found these compounds in range of 0.24+/-0.05-1.38+/-0.34microM against hCAI, 0.194+/-0.018-1.03+/-0.06microM against hCAII, 0.043+/-0.01-0.154+/-0.02microM against AChE, 3.92+/-1.08-11.93+/-4.45microM against BChE, 0.082+/-0.0008-1.68+/-0.42microM against AR, and 6.93+/-2.74-17.17+/-6.70microM against alpha-glycosidase. As a result, isolated compounds displayed inhibition effects against studied all metabolic enzymes. They are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.
        
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Ozaslan MS, Saglamtas R, Demir Y, Genc Y, Saracoglu I, Gulcin I (2022) Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity Chem Biodivers
Ozaslan MS, Saglamtas R, Demir Y, Genc Y, Saracoglu I, Gulcin I (2022) Chem Biodivers