Background: Alzheimer's disease is a chronic neurodegenerative chronic disease with a heavy social and economic impact in our developed societies, which still lacks an efficient therapy. Method: This paper describes the Hantzsch multicomponent synthesis of twelve alkyl hexahydro-quinoline-3-carboxylates, 4a-l, along with the evaluation of their Ca(2+) channel blockade capacity, cholinesterase inhibition and antioxidant power. Results: Compound 4l showed submicromolar inhibition of butyrylcholinesterase, Ca(2+) channel antagonism and an antioxidant effect. Conclusion: Compound 4l is an interesting compound that deserves further investigation for Alzheimer's disease therapy.
        
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Pachon-Angona I, Maj M, Wnorowski A, Martin H, Jozwiak K, Ismaili L (2021) Synthesis of new Hantzsch adducts showing Ca(2+) channel blockade capacity, cholinesterase inhibition and antioxidant power Future Med Chem
Pachon-Angona I, Maj M, Wnorowski A, Martin H, Jozwiak K, Ismaili L (2021) Future Med Chem