Paper Report for: Pani_2009_Int.J.Neurosci_119_1362
Reference
Title: Influence of intrastriatal infusion of dynorphin fragments on overflow of acetylcholine and dopamine in the rat brain Pani AK Ref: International Journal of Neuroscience, 119:1362, 2009 : PubMed
Dynorphin (DYN) fragments are the members of the endogenous opioid system and postulated ligands for the opioid receptors. Infusion of DYN(1-17) fragment into the rat dorsal striatum caused a significant increase in acetylcholine and decrease in dopamine overflow. Contrary to this, infusions of DYN(2-17) fragment into the rat dorsal striatum caused a significant increase in dopamine and decrease in acetylcholine overflow. Intrastriatal infusions of different doses of the acetylcholinesterase blocker, neostigmine, augmented acetylcholine and inhibited dopamine overflow in a dose-dependent manner. The opposing responses of the DYN fragments suggest that the N-terminal residue plays a key role in presynaptic neuromodulation.
        
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Pani AK (2009) Influence of intrastriatal infusion of dynorphin fragments on overflow of acetylcholine and dopamine in the rat brain International Journal of Neuroscience119: 1362-83
Pani AK (2009) International Journal of Neuroscience119: 1362-83