Paper Report for: Rosini_2014_Neurochem.Res_39_1914
Reference
Title: Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces Rosini M, Simoni E, Minarini A, Melchiorre C Ref: Neurochem Res, 39:1914, 2014 : PubMed
In recent years, the multi-target-directed ligand concept has been used to design a variety of molecules hitting different biological targets for Alzheimer's disease. We have sought to combine, in the same molecule, the neuroprotective action of N-methyl-D-aspartate receptor antagonism with the symptomatic relief offered by cholinergic activity through acetylcholinesterase inhibition. This strategy could potentially maintain the positive outcomes of memantine-acetylcholinesterase inhibitor combinations, but with the benefits of a single molecule therapy. Herein, we discuss selected examples of multifunctional compounds, which we rationally designed to simultaneously modulate these targets. We also examine the intertwined relationship between acetylcholinesterase, N-methyl-D-aspartate receptors, and other active players in the neurotoxic cascade.
        
Related information
Citations formats
Rosini M, Simoni E, Minarini A, Melchiorre C (2014) Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces Neurochem Res39: 1914-23
Rosini M, Simoni E, Minarini A, Melchiorre C (2014) Neurochem Res39: 1914-23