Paper Report for: Saleh_2013_Can.J.Neurol.Sci_40_684
Reference
Title: Less education predicts anticholinesterase discontinuation in dementia patients Saleh S, Kirk A, Morgan DG, Karunanayake C Ref: Can Journal of Neurology Sci, 40:684, 2013 : PubMed
Objective: We investigated patient socio-demographic, clinical and functional factors predicting cholinesterase inhibitor discontinuation by patients presenting to a memory clinic in Saskatoon, Saskatchewan. Methods: Data collection began in March 2004 at the Rural and Remote Memory Clinic where family physicians referred their non-institutionalized patients. Neurological and neuropsychological assessment, patient and caregiver questionnaires provided the socio-demographic, clinical and functional variables. Univariate logistic regression analysis was used to examine possible associations between each independent variable and the binary outcome variable of treatment discontinuation. Multivariate logistic regression was used to determine predictors of cholinesterase inhibitor discontinuation within six months of drug initiation. Results: Our sample consisted of the first 63 patients (60.3% female) for whom we prescribed a cholinesterase inhibitor. The mean age at clinic day was 74.56 years (SD=7.78). We found that years of formal education was the only variable significantly associated with cholinesterase inhibitor discontinuation by six months. The more years of formal education, the lower the rate of drug discontinuation by six months. Conclusions: Likelihood of cholinesterase inhibitor discontinuation by six months was predicted by fewer years of formal education.
        
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Saleh S, Kirk A, Morgan DG, Karunanayake C (2013) Less education predicts anticholinesterase discontinuation in dementia patients Can Journal of Neurology Sci40: 684-90
Saleh S, Kirk A, Morgan DG, Karunanayake C (2013) Can Journal of Neurology Sci40: 684-90