Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
        
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Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E (2008) 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity Bioorganic & Medicinal Chemistry Lett18: 309-12
Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E (2008) Bioorganic & Medicinal Chemistry Lett18: 309-12