Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze acetylcholine (ACh) in neural synaptic clefts and are primarily found in erythrocytes and blood plasma, respectively. Besides inactivating ACh, cholinesterases may play a non-classical role in inflammation and in immune response. In a previous study, we reported that BChE levels were decreased in chronic Chagas disease patients presenting the mega syndromes. In this series, we reported that: i) the activity of AChE did not differ between patients and controls, irrespective of the presence or not of the 1057C > A ACHE polymorphism, and ii) the increased BChE levels modestly influenced the AChE activity in Chagas disease.
        
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Seabra HF, Campello AC, Chagas EFG, Martins LPA, Suzuki RB, Ruiz MO, Donadi EA, Baleoti W (2022) The role of cholinesterases in chagas disease Parasitol Int
Seabra HF, Campello AC, Chagas EFG, Martins LPA, Suzuki RB, Ruiz MO, Donadi EA, Baleoti W (2022) Parasitol Int