A series of 5-benzylidenerhodanine-3-acetamides bearing morpholino-, 4-arylpiperazinyl-, or 4-benzylpiperidinyl- moieties were synthesized and their inhibitory activities against acetylcholinesterase (AChE) were evaluated. Alteration of amide part and substitution on the benzylidene moiety resulted in change of anti-AChE activity. The most active compound was the 1-benzylpiperidinyl derivative containing 4-(dimethylamino)benzylidene scaffold. Notably, the intermediate compounds, namely 5-arylidene-rhodanine-3-acetic acids (3), showed mild inhibitory activity against 15-lipoxygenase (15-LOX), while the final compound 4 showed no activity against 15-LOX.
        
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Shafii N, Khoobi M, Amini M, Sakhteman A, Nadri H, Moradi A, Emami S, Saeedian Moghadam E, Foroumadi A, Shafiee A (2015) Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors J Enzyme Inhib Med Chem30: 389-95
Shafii N, Khoobi M, Amini M, Sakhteman A, Nadri H, Moradi A, Emami S, Saeedian Moghadam E, Foroumadi A, Shafiee A (2015) J Enzyme Inhib Med Chem30: 389-95