Paper Report for: Sheridan_2005_Eur.J.Pharmacol_511_99
Reference
Title: Effects of seven drugs of abuse on action potential repolarisation in sheep cardiac Purkinje fibres Sheridan RD, Turner SR, Cooper GJ, Tattersall JE Ref: European Journal of Pharmacology, 511:99, 2005 : PubMed
Seven drugs of abuse have been examined for effects on the action potential in sheep isolated cardiac Purkinje fibres. Phencyclidine (5 microM) induced a significant increase (30.7%) in action potential duration at 90% repolarisation (APD(90)). Similarly, 10 microM 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') induced a significant increase in APD(90) of 12.1%. Although Delta(9)-tetrahydrocannabinol (0.1 microM) induced a small, but statistically significant, 4.8% increase in APD(90), no effects were observed at 0.01 or 1 microM. Cocaethylene (10 microM) induced a significant shortening of APD(90) (-23.8%). Cocaine (up to 1 microM), (+)-methamphetamine ('Speed'; up to 5 microM), and the heroin metabolite, morphine (up to 5 microM), had no statistically significant effects. The possible significance of these findings is discussed in the context of other recognised cardiac effects of the tested drugs.
        
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Sheridan RD, Turner SR, Cooper GJ, Tattersall JE (2005) Effects of seven drugs of abuse on action potential repolarisation in sheep cardiac Purkinje fibres European Journal of Pharmacology511: 99-107
Sheridan RD, Turner SR, Cooper GJ, Tattersall JE (2005) European Journal of Pharmacology511: 99-107