Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Abeta) (1 - 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Abeta (1 - 42).
        
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Shin EJ, Jhoo JH, Nabeshima T, Jhoo WK, Kwon MS, Lim YK, Chae JS, Jung ME, Park SJ, Jang KJ, Kim HC (2005) Growth hormone releaser attenuates beta-amyloid (1 - 42)-induced memory impairment in mice J Pharmacol Sci99: 117-20
Shin EJ, Jhoo JH, Nabeshima T, Jhoo WK, Kwon MS, Lim YK, Chae JS, Jung ME, Park SJ, Jang KJ, Kim HC (2005) J Pharmacol Sci99: 117-20