Paper Report for: Sidell_1984_Exp.Cell.Res_155_305
Reference
Title: Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell line Sidell N, Lucas CA, Kreutzberg GW Ref: Experimental Cell Research, 155:305, 1984 : PubMed
The ability of retinoic acid (RA) to modulate acetylcholinesterase (AChE) activity in a human neuroblastoma cell line (LN-N-5) was examined. The specific activity of AChE was significantly increased 3 days after exposure of LA-N-5 to RA and reached its maximum values after 9 or more days of culturing. Dose-response experiments demonstrated that large increases of AChE occurred at RA concentrations between 10(-7) and 10(-6) M with maximum AChE values detected at 10(-6)-10(-5) M. Increased AChE activity paralleled neurite outgrowth in LA-N-5 cultures. These findings demonstrate that RA can regulate specific AChE activity in human neuroblastoma cells in a manner consistent with neuronal maturation.
        
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Sidell N, Lucas CA, Kreutzberg GW (1984) Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell line Experimental Cell Research155: 305-9
Sidell N, Lucas CA, Kreutzberg GW (1984) Experimental Cell Research155: 305-9