Title: Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells Sims SM, Singer JJ, Walsh JV, Jr. Ref: Science, 239:190, 1988 : PubMed
The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.
        
Related information
Citations formats
Sims SM, Singer JJ, Walsh JV, Jr. (1988) Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells Science239: 190-3
Sims SM, Singer JJ, Walsh JV, Jr. (1988) Science239: 190-3