Paper Report for: Solntseva_2006_Bull.Exp.Biol.Med_142_387
Reference
Title: Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane Solntseva EI, Bukanova YV, Skrebitskii VG Ref: Bulletin of Experimental Biology & Medicine, 142:387, 2006 : PubMed
The effects of donepezil on voltage-dependent Ca(2+)- and low-threshold K(+)-current were studied on isolated molluscan neurons using two-electrode voltage clamp technique. Donepezil reduced the amplitude of voltage-dependent Ca(2+)-current (IC(50)=7.9 microM) and shifted the current-voltage relationships toward hyperpolarization. Donepezil in low concentration (5 microM) increased, while in higher concentrations (>or=10 microM) decreased the low-threshold K(+)-current.
        
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Solntseva EI, Bukanova YV, Skrebitskii VG (2006) Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane Bulletin of Experimental Biology & Medicine142: 387-90
Solntseva EI, Bukanova YV, Skrebitskii VG (2006) Bulletin of Experimental Biology & Medicine142: 387-90