Paper Report for: Steirer_2009_J.Biol.Chem_284_3777
Reference
Title: The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid alpha2,6-galactose Steirer LM, Park EI, Townsend RR, Baenziger JU Ref: Journal of Biological Chemistry, 284:3777, 2009 : PubMed
The asialoglycoprotein receptor (ASGP-R) is an abundant, carbohydrate-specific, endocytic receptor expressed by parenchymal cells of the liver. We recently demonstrated that the ASGP-R mediates the clearance of glycoproteins bearing Siaalpha2,6GalNAc as well as those bearing terminal Gal or GalNAc. We now report that glycoproteins such as haptoglobin, serum amyloid protein (SAP), and carboxylesterase that bear oligosaccharides with terminal Siaalpha2,6Gal are elevated in the plasma of ASGP-R-deficient mice. Because of their abundance in plasma, glycoproteins bearing terminal Siaalpha2,6Gal will saturate the ASGP-R and compete with each other on the basis of their relative affinities for the ASGP-R and their relative abundance. We propose that the ASGP-R mediates the clearance of glycoproteins that bear oligosaccharides terminating with Siaalpha2,6Gal and thereby helps maintain the relative concentrations of these glycoproteins in the blood.
        
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Steirer LM, Park EI, Townsend RR, Baenziger JU (2009) The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid alpha2,6-galactose Journal of Biological Chemistry284: 3777-83
Steirer LM, Park EI, Townsend RR, Baenziger JU (2009) Journal of Biological Chemistry284: 3777-83