Asians are known to be more likely than Westerners to develop fatty liver and lifestyle-related diseases in spite of their weight. However, the relationship between fat accumulation and lifestyle-related diseases in non-obese Asians is unknown. Therefore, this study aimed to analyze visceral fat and hepatic fat in participants with a normal body mass index (BMI) and examine their characteristics during a medical checkup. This cross-sectional study was conducted on 663 of 1142 patients who underwent abdominal ultrasonography and who had an alcohol intake (converted to ethanol) of <30 g/day for males and <20 g/day for females and a BMI of <25 kg/m(2) during a health checkup. Participants were classified into four groups: group A, visceral fat accumulation (VFA) (-) and fatty liver (FL) (-) (n = 549); group B, VFA (+) and FL (-) (n = 32); group C, VFA (-) and FL (+) (n = 58); and group D, VFA (+) and FL (+) (n = 24). The frequencies of lifestyle-related disease complications, liver function tests, and liver fibrosis were evaluated among the four groups. Compared with group A (control), groups B, C, and D had a higher number of males, BMI, abdominal circumference, ALT, AST, gamma-GTP, triglyceride, uric acid, fasting blood sugar levels, and incidence of hyperlipidemia. Groups C and D had higher ALT, HbA1c, cholinesterase, and triglyceride levels, FIB4 index, and the number of patients with diabetes mellitus (DM) than groups A and B; however, there was no difference between groups A and B. FL is a risk factor of DM and liver fibrosis in non-obese Japanese individuals; however, VFA only is not a risk factor of DM and liver fibrosis.
        
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Urata N, Kawanaka M, Nishino K, Ishii K, Tanikawa T, Suehiro M, Sasai T, Haruma K, Kawamoto H, Nakamura J, Manabe N, Kamada T (2020) Fatty Liver, and Not Visceral Fat, Is More Associated with Liver Fibrosis and Diabetes in Non-Obese Japanese Individuals: A Cross-Sectional Study Life (Basel)10:
Urata N, Kawanaka M, Nishino K, Ishii K, Tanikawa T, Suehiro M, Sasai T, Haruma K, Kawamoto H, Nakamura J, Manabe N, Kamada T (2020) Life (Basel)10: