Paper Report for: Vernekar_2016_Angew.Chem.Int.Ed.Engl_55_1412
Reference
Title: Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the Degradation of Nerve Agents Vernekar AA, Das T, Mugesh G Ref: Angew Chem Int Ed Engl, 55:1412, 2016 : PubMed
Organophosphorus-based nerve agents, such as paraoxon, parathion, and malathion, inhibit acetylcholinesterase, which results in paralysis, respiratory failure, and death. Bacteria are known to use the enzyme phosphotriesterase (PTE) to break down these compounds. In this work, we designed vacancy-engineered nanoceria (VE CeO2 NPs) as PTE mimetic hotspots for the rapid degradation of nerve agents. We observed that the hydrolytic effect of the nanomaterial is due to the synergistic activity between both Ce(3+) and Ce(4+) ions located in the active site-like hotspots. Furthermore, the catalysis by nanoceria overcomes the product inhibition generally observed for PTE and small molecule-based PTE mimetics.
        
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Citations formats
Vernekar AA, Das T, Mugesh G (2016) Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the Degradation of Nerve Agents Angew Chem Int Ed Engl55: 1412-6
Vernekar AA, Das T, Mugesh G (2016) Angew Chem Int Ed Engl55: 1412-6