Title: Mutagenic activity of phosmet, the active component of the organophosphorus insecticide Decemtione EK 20 in Salmonella and Saccharomyces assays Vlckova V, Miadokova E, Podstavkova S, Vlcek D Ref: Mutat Res, 302:153, 1993 : PubMed
Phosmet, the active component of the organophosphorus insecticide Decemtione EK 20, was shown to be mutagenic in the standard Ames Salmonella/mammalian microsome assay in the absence and presence of metabolic activation. It appears to be a direct mutagen inducing base substitution mutations (TA100) as well as a weak frameshift mutagen (TA97). This compound was genotoxic in the Saccharomyces cerevisiae D7 strain. It significantly increased reverse mutation, mitotic crossing-over and slightly, but not significantly, increased gene conversion at the highest concentration used.
Vlckova V, Miadokova E, Podstavkova S, Vlcek D (1993) Mutagenic activity of phosmet, the active component of the organophosphorus insecticide Decemtione EK 20 in Salmonella and Saccharomyces assays Mutat Res302: 153-6
Vlckova V, Miadokova E, Podstavkova S, Vlcek D (1993) Mutat Res302: 153-6