Paper Report for: Wang_1992_Brain.Res.Mol.Brain.Res_16_64
Reference
Title: Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains Wang SZ, Zhu SZ, Mash DC, El-Fakahany EE Ref: Brain Research Mol Brain Res, 16:64, 1992 : PubMed
We determined the concentration of the messenger RNA species which encode four (m1-m4) of the five cloned muscarinic receptors in brains of Alzheimer's disease patients as compared to age-matched controls. Assays were performed using the quantitative method of DNA-excess solution hybridization in the cerebral cortex (frontal, temporal and occipital), hippocampus, nucleus basalis of Meynert and brainstem. The results suggest a statistically significant decrease in the m1 muscarinic receptor message in the temporal and occipital cortex, with no change in other regions. There was no change in the level of mRNA encoding the m2, m3 or m4 receptors in any of the brain regions studied.
        
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Wang SZ, Zhu SZ, Mash DC, El-Fakahany EE (1992) Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains Brain Research Mol Brain Res16: 64-70
Wang SZ, Zhu SZ, Mash DC, El-Fakahany EE (1992) Brain Research Mol Brain Res16: 64-70