Paper Report for: Wolthuis_1981_Eur.J.Pharmacol_69_379
Reference
Title: Persistence of the anti-cholinesterase soman in rats; antagonism with a non-toxic simulator of this organophosphate Wolthuis OL, Benschop HP, Berends F Ref: European Journal of Pharmacology, 69:379, 1981 : PubMed
Anaesthetized, atropinized rats were poisoned with 6x LD50 soman (1,2,2,-trimethylpropyl methylphosphonofluoridate). Purified acetylcholinesterase, injected i.v. 75 min later, was rapidly inhibited, presumably by soman stored in a 'depot' from which it was gradually released. Existence of a depot is supported by the effect of a soman-simulator ('som-sim'), an organophosphonate structurally similar to soman but devoid of anti-cholinesterase activity. Som-sim can expel soman from the depot, or counteract its formation. Som-sim prophylaxis greatly enhances survival.
Wolthuis OL, Benschop HP, Berends F (1981) Persistence of the anti-cholinesterase soman in rats; antagonism with a non-toxic simulator of this organophosphate European Journal of Pharmacology69: 379-83
Wolthuis OL, Benschop HP, Berends F (1981) European Journal of Pharmacology69: 379-83