Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC(50) value of 7.28 +/- 0.94 micromol.(-1).
        
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Xia H, Zhang JF, Wang LY, Xia GY, Wang YN, Wu YZ, Lin PC, Xiong L, Lin S (2022) Bioactive neolignans and lignans from the roots of Paeonia lactiflora Chin J Nat Med20: 210-214
Xia H, Zhang JF, Wang LY, Xia GY, Wang YN, Wu YZ, Lin PC, Xiong L, Lin S (2022) Chin J Nat Med20: 210-214