Paper Report for: Yue_2006_Hepatobiliary.Pancreat.Dis.Int_5_52
Reference
Title: Transient elevation of hepatic enzymes in volunteers after intake of alcohol Yue M, Ni Q, Yu CH, Ren KM, Chen WX, Li YM Ref: Hepatobiliary Pancreat Dis Int, 5:52, 2006 : PubMed
BACKGROUND: In the organs that mediate alcohol effects on the human body and its health, the liver plays a particular important role. This study was designed to detect the changes of hepatic enzymes after alcohol intake and evaluate the corresponding damage to the human body. METHODS: Fifteen volunteers were included according to the criteria. After the intake of 80 g ethanol containing beverage, alcohol levels were detected and blood samples were collected at 0.5- to 3-hour interval to detect the levels of hepatic enzymes simultaneously. RESULTS: After the intake of 80 g ethanol, various symptoms occurred in volunteers while the concentration of blood alcohol peaked at 1 hour and normalized within 24 hours. The ratio of alanine aminotransferase (ALT) to aspartate aminotransferase (AST) increased significantly when the venous alcoholic concentration increased from 0 g/L to 1.2 g/L and the levels of alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (gamma-GT) were elevated when the alcoholic concentration reached 0.4 g/L. No significant changes were noticed in ALT, AST or cholinesterase (CHE). CONCLUSION: Acute alcohol intoxication may cause the changes of hepatic enzymes and prove the existence of reversible hepatic injury.
        
Related information
Citations formats
Yue M, Ni Q, Yu CH, Ren KM, Chen WX, Li YM (2006) Transient elevation of hepatic enzymes in volunteers after intake of alcohol Hepatobiliary Pancreat Dis Int5: 52-5
Yue M, Ni Q, Yu CH, Ren KM, Chen WX, Li YM (2006) Hepatobiliary Pancreat Dis Int5: 52-5