Paper Report for: Zhang_2004_Zhejiang.Da.Xue.Xue.Bao.Yi.Xue.Ban_33_205
Reference
Title: [Influence of chronic epilepsy on spatial memory retrieval in rats] Zhang LS, Jin CL, Li Q, Sun YC, Chen Z Ref: Zhejiang Da Xue Xue Bao Yi Xue Ban, 33:205, 2004 : PubMed
OBJECTIVE: To investigate the influence of chronic epilepsy on spatial memory retrieval in rats, and to evaluate the effects of TAK-147, an acetylcholinesterase inhibitor, and histidine, the precursor of histamine, on the amnesia induced by epilepsy. METHODS: After successfully trained in the 8-arm (4-arm baited) radial maze, the rats were ip injected with a subconvulsive dose of pentylenetetrazole (PTZ) every 48 h until fully kindled. Memory retrieval was tested at the same maze. RESULT: Impairment of memory retrieval was in a steady state 1 to 18 days after fully kindled, the ability of memory retrieval returned to the control level 31 days after fully kindled. TAK-147 showed an ameliorating effect on memory impairment induced by epilepsy, including reference and working memory in a dose-dependent manner. Histidine only ameliorated reference but not working memory. CONCLUSION: PTZ-kindled seizure impair spatial memory retrieval, which it might be due to a decrease of brain acetylcholine and histamine induced by epilepsy.
        
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Zhang LS, Jin CL, Li Q, Sun YC, Chen Z (2004) [Influence of chronic epilepsy on spatial memory retrieval in rats] Zhejiang Da Xue Xue Bao Yi Xue Ban33: 205-8
Zhang LS, Jin CL, Li Q, Sun YC, Chen Z (2004) Zhejiang Da Xue Xue Bao Yi Xue Ban33: 205-8